An archaeological excavation was carried out in the city block Traktören in Enköping during 2017 and 2018. The occupation layers were dated to the 12th–18th centuries. During the excavation and the analysis of the faunal remains an unusually large quantity of wolf bones were identified. Wolf is rarely found in bonematerials dating to the medieval period, but according to written sources from the Middle Ages the wolf population was growing and becoming a problem during this time. Swedish medieval laws state that wolves had to be hunted each year to keep the population down. With the large number of bones of wolf found in Traktören it is possible to study the relationship between wolf and man. Age and sex distribution indicate the killing of whole packs of wolves in driven hunts in accordance with written sources, with the aim of exterminating the wolf. Analysis of strontium isotopes and osteological remains shows that the wolves were hunted in the close surroundings to Enköping and taken back to the city where the furs were removed and the bodies dismembered. Fur was a valuable income and during the 13th and 14th centuries Enköping was a junction for trade because of its port. The largescale trade in fur seems to have come to an end in the latter part of the 15th century. One reason for the disappearance of the wolf in the material could be that the tannery moved to another part of the town, but the main reason appearsto be the port being moved further from the city.